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KBP-7018 hydrochloride

CAS No. 1613437-67-4

KBP-7018 hydrochloride( KBP 7018 hydrochloride | KBP7018 hydrochloride )

Catalog No. M12342 CAS No. 1613437-67-4

A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KBP-7018 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.
  • Description
    A novel potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively; also potently inhibits FLT3, VEGFR2, Fyn, PDGFRα and VEGFR2; shows promising outcomes for the treatments of idiopathic pulmonary fibrosis (IPF).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KBP 7018 hydrochloride | KBP7018 hydrochloride
  • Pathway
    Angiogenesis
  • Target
    c-Kit
  • Recptor
    c-Kit
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1613437-67-4
  • Formula Weight
    575.06
  • Molecular Formula
    C31H31ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC(=O)C1=CC2=C(C=C1)C(=C(N2)O)C(=NC3=CC4=C(C=C3)N(CC4)C(=O)CN5CCOCC5)C6=CC=CC=C6.Cl
  • Chemical Name
    Methyl (Z)-3-(((1-(2-morpholinoacetyl)indolin-5-yl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang Z, et al. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147. 2. Huang Z, et al. Drug Des Devel Ther. 2015 Aug 5;9:4319-28.
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